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Mark- I would suspect the culprit is the Clozaril increase. It can be very sedating and PWP are often extremely sensitive to both the therapeutic effects and the side effects of the drug. It is a tough balancing act to increase the Sinemet (which sounds necessary) and preventing hallucinations. Discuss your concerns with his doctor. It sounds like he is competent and if he doesn't discount your concerns you should work with him. He needs feedback as to your observations to adequately walk this pharmacological tightrope. Good luck, Charlie Mark Klapper wrote: > > > All: > > > > The docs are concerned that my father is freezing up in bed during the > > night, resulting in much stiffness in the morning and some problems > > with incontinence. They added a fourth Sinimet 25/250 at around 9PM. > > To counteract the side effects, they've also doubled his Clozaril to > > 25 mg. > > > > The nights are no longer a problem, but he is very groggy most of the > > morning and has again become confused and irritable. I'd like to > > suggest an alternative...does anyone have any experience with this? > > > > Mark Klapper -- CHARLES T. MEYER, M.D. Middleton, WI [log in to unmask]