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At the local (Tucson) APDA educational meeting this month the speaker was Dr. Stuart Snider, who is probably our most parkinson-savvy neurologist these days. His message was about what to do if neither Mirapex nor Requip had worked out for you, and there was a huge turnout to hear him. Having flunked both agonists, I was very interested in his opinions. His first point was that both of the new agonists seemd to offer some advantages over the old ones, especially in the area of neuro-protection, and ability to replace sinemet. But he said that there was nothing wrong with continuing or returning to Parlodel or Permax if the new ones didn't work. The advice that was most significant to me was that he felt that people were titrating up way too fast on both drugs, and he suggested going real slow. I took him up on it, and started Requip again, and am titrating up at an almost invivible pace, but at least I am still using it, and adapting to it. After about 6 weeks, I am still only taking 8 or 9 of those little ones a day, but no side effects. Soon I will get real brave, and add a pill or two :) When we need help it is hard to go slow, but these drugs are so powerful, I think sometimes it is unrealistic to expect to adapt as quickly as we would like. Kathie Tollifson [log in to unmask] 47/9