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Kathie-- you are titrating up on Requip at the speed Peter has done--and he too has done well--some of us are just "slower" than others, and it's a good thing! Good luck. We've reduced Sinemet to 1000 mg X day, from 1600, very gradually, and the neuro said that when P. slowed down, it would be a sign to add another Requip, at the time we had cut the last Sinemet. At the local (Tucson) APDA educational meeting this month the speaker was >Dr. Stuart Snider, who is probably our most parkinson-savvy neurologist >these days. His message was about what to do if neither Mirapex nor Requip >had worked out for you, and there was a huge turnout to hear him. Having >flunked both agonists, I was very interested in his opinions. His first >point was that both of the new agonists seemd to offer some advantages over >the old ones, especially in the area of neuro-protection, and ability to >replace sinemet. But he said that there was nothing wrong with continuing or >returning to Parlodel or Permax if the new ones didn't work. The advice that >was most significant to me was that he felt that people were titrating up >way too fast on both drugs, and he suggested going real slow. > >I took him up on it, and started Requip again, and am titrating up at an >almost invivible pace, but at least I am still using it, and adapting to >it. After about 6 weeks, I am still only taking 8 or 9 of those little ones >a day, but no side effects. Soon I will get real brave, and add a pill or >two :) > >When we need help it is hard to go slow, but these drugs are so powerful, I >think sometimes it is unrealistic to expect to adapt as quickly as we would >like. > >Kathie Tollifson >[log in to unmask] >47/9 Camilla Flintermann, CG for Peter 79/8 Oxford, OH [log in to unmask] * * * * * * * * * * * * * * * * * * Ask me about the CARE list for* * Parkinson's caregivers ! * * * * * * * * * * * * * * * * * *