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My mother Joyce (68/11 months) has been on Requip only for over a month and is only up to 1.25 mg./dose (she takes it either 3 or 4 times a day). She is working her way up to her final dose (whatever that will be) very slowly. In an effort to determine what exactly is causing her tightness in the chest, her doctor took her off all other drugs before starting her up on Requip (she had been on Sinemet, Eldepryl, and Permax). She still experiences the tightness in her chest, which bothers her quite a bit and makes breathing difficult. She is planning to call her doctor tomorrow to say that she wants the Sinemet back -- that she just cannot take this anymore. This sounds reasonable to me. She gave it a shot, and taking the Requip alone just isn't cutting it (although she is aware that things could get better once on full dosage). The question is, is it reasonable to ask my mother to stay off Sinemet for, possibly, another month or two just to see what is causing what when, in fact, she might find some relief by combining Requip and Sinemet. Thanks for any thoughts on this. Debbie White [log in to unmask]