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This week I received the United Parkinson Foundation newsletter. All it contains is info about COMT inhibitors (Tolcapone and Entacapone) It said it is likely to be released shortly in the U.S. It states that the combination of Sinemet CR with a COMT inhibitor could conceivably be a better solution for wearing off then either of these strategies along. However, the effectiveness of COMT inhibitors might make such a combination unnecessary. It also say that the most common side effects from the COMT inhibitors are effects resulting from increased actions of levodopa. These include enhanced involuntary movements (dyskinesias), nausea, vivid dreams or hallucinations. Such side effects can be lessened by lowering the dosage of levodopa. Other side effects seem specific to tolcapone. Up to ten percent of patients taking this drug experienced diarrhea. This can be a mild problem of brief duration and discontinuing tolcapone gives prompt recovery from diarrhea. Some patients have been unable to continue with tolcapone because of this side effect. It's a four page newsletter with lots of into. They are out of Chicago. There phone number is 312 733-1893. You might call for a copy. Nancy B cg for Don 64/14 -----Original Message----- From: Diane Lucas <[log in to unmask]> To: Multiple recipients of list PARKINSN <[log in to unmask]> Date: Friday, January 30, 1998 1:29 AM Subject: Re: STEVE SHER >Dear All, > >Does anyone have any further info on Tolcapone and Sinnet taken together. > >I am quite concerned about my Mum. > >Thanks > >Diane >