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tolcapone is a COMT inhibitor. it increases the effect of levodopa dosage. i suggest she halve her dosage, but take the Sinemet on the same schedule - just half as much. this should reduce the nausea. -- Ron Vetter 1936, '84 PD dz paradise is feeling good, not a place to go [log in to unmask] http://www.ridgecrest.ca.us/~rfvetter