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Steve, my dad gets B-12 shots periodically, I don't know how effective it is, but at least that means it is considered a standard procedure for PD. I don't have PD, but I take DHEA evry day, and I find it gives me more energy. It is supposed contain a hormone. I get about 5 1/2 hours of sleep during the week and am able towork all day without getting too tired. I buy it at Sam's Club for about $13 for 300 pills, I think they are 25mg. [log in to unmask]