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Hello, I am happy to have found this list. Reading other messages I can tell already that this is a wonderful place to receive information and support. A quick introduction: My mother, age 79, has had Parkinsons for about 7/8 years now. She has managed her condition well until recently, but I have gradually had to assume more of her care and have become an active participant in helping her try to manage her Parkinsons. At the moment we are at kind of a low point which is very frustrating for her and me also. She is now at a point where her medications [sinemet(25/100 3 X per pay and CR 4 X per day) and eldepryl (once a day] are no longer very effective and she is hoping for help from newer medications. Her situation is complicated by her high blood pressure for which she has taken medication for about 20 years. The doctor calls her type of blood pressure labile, meaning it goes up and down all the time. However, it was being managed within an acceptable range. She started on mirapex last fall, but as time went by her blood pressure began to fluctuate. She was taking mirapex 3X per day, gradually increasing the dosage. What she found was that after taking her noon dose her blood pressure would drop rapidly, and then rise gradually through the afternoon, and sometimes get too high in the evening. Her doctor (who is not a neurologist) was convinced that the mirapex was causing her fluctuations in BP through the day. We were not convinced that it was the culprit because her BP did not dive after her morning and evening dose, only at noon, and in fact would rise in the evening after taking the mirapex. The doctor reduced her blood pressure medication because it was going so low, but it continued to get too high at times. She had a couple of TIAs accompanied with numbness, headaches, confusion, and then 2 weeks ago ended up in the emergency room with a near stroke and week's hospitalization, from which she has emerged with no apparent effects except extreme weakness (and terrible memories of the hallucinations she experienced there). However, she has not taken mirapex since she went into the hospital, which probably partly accounts for some of her weakness, and she is on her old routine. She was having a good energy boost with mirapex and felt much better during her "good" times. She has been home from the hospital for about 2 weeks and her blood pressure is still leaping around dropping so low at times that she can barely move and then going high at other times. She is taking more BP medications now, but it is still not keeping it in an acceptable range. Her neurologist has left the BP problem to her other doctor to work on (suggesting she hold off on restaring mirapex), and her other doctor has essentially tossed in the towel on controlling her blood pressure and has now referred her to a kidney specialist. After that long winded introduction (sorry) my question is rather short. I know others have had trouble with lowering of BP with mirapex, but has anyone ever experienced such fluctuations in BP while taking it? We are sort of at a standstill, going to one doctor who sends us to the next, and in the meantime she barely gets around in the day, can't sleep at night and has difficultry concentrating on the simplest tasks, and I think is getting increasing depressed. Any comments, suggestions offered would be appreciated. I also just appreciate having a place where I can even discuss this!! Thanks in advance for any help. Jan