When my father was discharged from the hospital, the doc finally agreed to switch his med schedule from 1 Sinemet 25/250 4x (45 mins before a meal and bedtime) to 1 tab at 7AM, 1/2 at 10, 1, 4 and 7, and 1 at bedtime. I'm not confident about how precisely this schedule is being adhered to -- they are trying, but I think that there is a margin of error of as much as 45 minutes, and that he could be getting the 1PM dose right after lunch. I'm wondering if the fluctuations in dopamine levels through the day could be making the confusion and his PD symptoms worse, rather than better. (He has been freezing up and I'm told that people have noticed tremors). He had been doing fairly well on the 4x/day schedule, and I had hoped that smaller more frequent doses would improve things. Would he be better off on the original schedule? Mark Klapper