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Hi Dale Severance Could you (or anyone else) clarify the term "wearing off" with regard to Requip, please? I also take it, and I'm not clear whether you mean long term reduction in effectiveness/benefit or a much shorter term like the end-of-dose "OFF". I find that the "window" of effectiveness of my meds (Madopar and Requip) has a much quicker tail-off than with other drug combinations, notably Madopar alone and Madopar with Pergolide (which gave me other problems). Thus my ON periods are much more clearly defined and time- critical than before. If I forget my meds I am much quicker aware of the lack. Jeremy >I quess you can see from my messages that I am wired up this morning. > >Several weeks ago a few comments were made on the net >about requip wearing off. At that time I asked requip salesman what he had >heard on that subject. I advised the list that he reported no notice of such a >problem. > >I learned yesterday that several manufacture's repre's are meeting with my >doctor to discuss this very issue. Apparently the wearing off effect is >beginning to get the manufactures attention. I personally am slipping back >from my original requip level and I have been on requip about three months >now. > >Dale Severance > -- Jeremy Browne - [log in to unmask] Hampshire, UK