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On Mon 09 Feb, Brian Collins wrote: > > > I suggest that you talk to your neurologist along the lines of cutting > the Sinemet dose to no more than 50 mg every 2 to 2 1/2 hours, and > making up the difference with one of the Dopamine agonists. I use Permax > myself, but it all depends on Bob's reaction to it. Most people find > at least one of the agonists wich works for them. The transition from > the current dosage to the new one would need careful management. > > I hope you find this useful - Does anyone have any data on 'Burnout > through overdosing? > > Regards, > > -- > Brian Collins <[log in to unmask]> > > > I was reminded by Doug McCorkle of something that I should have mentioned before: I also find it best to take a single Madopar CR 25/100 just befire I go to sleep: it is relaxing , but does not set my mind ticking over too fast as a full dose would do (Its about half a daytime dose.) You will note that both Doug's Mother and I are starting at a much lower dosage of Sinemet/Madopar than Bob (although after 19 yrs, I do take a lot of Permax as well.) Madopar is a different trade name containing levodopa, and is available in UK, Canada, France, and maybe other countries. I don't recommend one as being better than the other, although Madopar's 'Dispersible' is a very useful tablet. It can be broken down to small quantities (a full tablet is 50 mg levodopa: 12.5 mg Benserazide (works just like Carbidopa), and I take them without water (It's like sucking an acid drop.) Age 58; Diagnosed; 19yrs. First symptoms; 25 yrs. Regards -- Brian Collins <[log in to unmask]>