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At 18:40 6-2-98 -0600, you wrote: >Yes, I too am very restless when sitting. Not exactly pain, more like >muscle tension, it's hard to describe. > >Ken Rowland >[log in to unmask] Ken, Nothing in this mail has not been said before on the list. Listmembers who followed the discussion about two-fase dyskinesia can skipp it. Maybe my story can be helpfull for you. It is possible too that your symptoms don't have anything in common with mine. The way you describe your symptoms made me think I recognized it, but maybe undeservedly. If you want to know more, feel free to ask. The tension in my muscles and always feeling an urge to move when sittng, up to the point that I clamped myself to the armrests to keep myself seated, all my muscles being tense especially those in my legs. I suffered from this in the first years of my life as a Parkinson patient. Of course I thought it meant I had to much leva-dopa and I experimented with different dosages. I did not found a dosage which gave me the profit of movement without these symptoms. One method to influence them was taking one day only a small dosis and endure the Parkison symptoms and than the next day a higher than normal dosis. So I might have some good hours. Another method was:to move as long as I could do so, for example keep walking. It was an exhausting life. My neuro said it was caused by the leva dopa, but it manifested itself when the leva-dopa was under a certain level after having been above it Other drugs can have the same kind of effects, for example heroin and to a lesser extent also alcohol. When I saw in reality or in a movie a heroine addict who needs his next shot, I did recognize the symptoms. Being in this fase in a public place, people often asked me: "are you cold?" So I called this symptoms" my cold turkey". Years passing by the symptoms changed into something that could be best described as dyskinesia, involuntary movement. This in itself is normal after years of use of leva-dopa , but it was not the same kind of dyskinesia. I could know that very well because sometimes I experienced that too. Quite some time ago I wrote to the list that it was my impression that two kinds of dyskinesia existed, one combined by dystonia, the other not. There was, as far as I remember, no reaction. But months after that I did read in a mail from David Langridge, to my surprise, the text I have quoted below. After reading this I followed the instructions about med. schedules. The results were unbelievable. The daily time of my wild dyskinesia was reduced from 8 hours to 2 hours. To identify a dyskinesia as a wearing off one, one has to attend to the time that passes from the intake of sinemet to= =20 the start of the dyskinesia concerned. Ida Kamphuis, Holland Quote from David Langridge: There is however a fly in the ointment because the effecftiveness of each dose of sinemet is curtailed because mainly at the end of a dose when it's effect is beginning to wear off I experience an unpleasant drug induced state akin to dyskinesia but not in it's wild form- I can best describe it as a sort of mainly internal writhing with incipient neck movements and body swaying all reasonably controllable although an outside observer mightguess that I was having a bad go of indigestion!Also more often than not my leftleg goes rigid and I find it harder to walk than if I had not taken Sinemet.So here is a drug induced problem which seeems to more or less fit the term diphasic dyskinesia which I first came upon in the 'Algorithm for Parkinsons Disease' a very worthy paper published in Neurology and obtainable from our archives. diphasic dyskinesia" or D-I-D response, a shorthand for "dyskinesia-improvement-dys=ADkinesia").[124] This pattern is much less common than peak-dose dyskinesia and is often difficult to diagnose because the pattern may not he obvious, either to the patient or the clinician, The end-of-dose period of dyskine=ADsias is typically more prolonged and troublesome than the initial dyskine=ADtic period of the levodopa cycle.=20 .It seems strange that although I have been following the list for almost two years I have seen no mention of this problem except in a=20 posting from Ida Kampuis in October and amongst many other interesting things she sais <<<< An important difference between the two states of hyperkinesia is that the end of meds one is combined with high muscle tension end=20 the other much less so. This makes the former the most troubling one. During the former walking is more impaired or impossible.>>>>. As mentioned above I have experienced this end of meds muscle tension.Also I have searched in the archives and found no mention of diphasic dyskenesia the only hit being the algorythm paper which I already had read. -------------------------------------------------------------- Vriendelijke Groeten / Kind regards, Ida Kamphuis mailto: [log in to unmask]