Marling McReynolds wrote: > ... doctors seems to prescribe larger than needed doses for first > time users, especially of sinemet. .... I was on 50/200 every 4 > hours in the beginning Sounds like a lot. How bad was your beginning? What were your symptoms a that time? > and after the initial good reaction (sinemet certainly controls the > pd symptoms) I experienced the worst of side-effects. Now I am on > the least of sinemet cr (25/100) and only take it at my worst time > of day, with requip the rest of the time It was true in my case with my first doc - a general neurologist. Problem is, in the beginning we may tolerate overdoses fairly well, and also be unaware of the differences between disease symptoms and medicine side effects, so we don't know what's an overdose. Now I'm at a point where the difference between too little sinemet and too much is narrowing. There are not enough gradations in size of available doses. 25/100 can be too little and 50/200 too much. Phil Tompkins Hoboken NJ 60/9