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Arthur Hirsch wrote: > One might postulate that there is a continuum of sorts for doses. > The lowest dose might be half of a 25/100, taken at some appropriate > interval. Next lowest might be the whole 25/100, but taken at a > greater interval. Then perhaps a half of a 50/200 or two halves of a > 25/100 taken at the shorter interval. Then a 50/200 taken at the > longer interval. And finally a 50/200 broken in two and both halves > taken together. Were 25/100 and 50/200 chosen as dose sizes because they are are nice round numbers, not because of what people need? I'm trying half a 50/200 CR at shorter intervals as an alternative to a whole 50/200, which is a bit too much for me. Perhaps if I could get the halves timed right, I'd find my ideal level. But I'm running into trouble. I find the more frequent half pill doses to be more than twice as hard to manage. The effects change more rapidly, and it's less predictable what will happen. Sometimes a half dose doesn't seem to kick in at all. Effects of other variables, such as what I eat and when (and whether I've got the time and am able to attend to and keep track of the doses) have become much more important. I'm also taking small doses of regular sinemet, which kicks in quicker, as a starter, plus Permax, which I'm not sure is doing very much. I think I'll head back to the neuro to re-work the schedule. Phil Tompkins Hoboken NJ 60/9