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I quess you can see from my messages that I am wired up this morning. Several weeks ago a few comments were made on the net about requip wearing off. At that time I asked requip salesman what he had heard on that subject. I advised the list that he reported no notice of such a problem. I learned yesterday that several manufacture's repre's are meeting with my doctor to discuss this very issue. Apparently the wearing off effect is beginning to get the manufactures attention. I personally am slipping back from my original requip level and I have been on requip about three months now. Dale Severance