 |
 |
Hi Bob, You ask an important question. My problem is that the therapeutic window with sinemet has closed- I have extremely severe dyskinesia and some dystonia on relatively low doses of Sinemet. The new agonists are not supposed to produce as much dyskinesia. Therefore in theory if the dose of the agonist is high enough the Sinemet dose can be minimized giving a treatment effect with less dyskinesia. It has seemed to help taking high doses of requip while when I stopped the mirapex the increasing doses did not seem to be making a significant difference. I did not have any significant side effects with the mirapex but I have had some significant sedation (which has now improved) with requip. Charlie Bob Bowling wrote: > > On Feb. 7, 1998 Charlie Meyer wrote: > > <<I had been up to 7 mg/day of mirapex(prescribed by Dr. Goetz - head of > the > Movement disorders program at Rush-Presbyterian in Chicago ) but it didn't > help > so we switched to Requip.>> > > Charlie, > > Please share with us your objectives with the 7 mg./day dose. Were you > targeting further improvement of a symptom that had responded favorably to > lower Mirapex doses? Did you experience side effects at higher doses that > were mild or nonexistent at lower doses? What differences did you > experience between Mirapex and Requip? > > Thanks for your help. > > Bob > ~~~~~~~~~~~~~~~~~~~~~~ > Bob Bowling 51/9 > Overland Park, KS > <[log in to unmask]> -- CHARLES T. MEYER, M.D. Middleton, WI [log in to unmask]