 |
 |
On Fri 13 Feb, Stephan Schwartz wrote: Stefan: I find myself in agreement with just about everything that you wrote in your message on 13th Feb. As Dame Edna might say- It's kinda spooky, isn't it? I do have onequestion : However did Dr Stern manage to measure the degree of neuroprotection which resulted from varying the dosage of selegiline ? As you will be aware from my previous posts, I am not a fan of Selegiline However, I do take Vitamin E to provide the same effect: I may be stupid, but I'm not crazy!! Actually, I am not completely sold on the free radical story. It may be a part of the story, but the current talk in the research field seems to be inclining towards the notion of a number (maybe 20 or so) of effects which can all contribute towards increasing the stress on the Dopaminergic cells in the Substantia Nigra. At a certain level of stress, the cell quietly gives up and dies (Apoptosis). the 20 causes are probably determined genetically ( I don't mean that they are inherited; merely that they are a series of locations in the DNA at which some stress-raising effect may occur, just due to the way that the dice happened to fall for any particular person. . If you have enough strikes against you: you will one day develop PD symptoms. Have you heard this line? Regards, -- Brian Collins <[log in to unmask]>