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Stress! Worry! Anxiety! Excitement - good or bad ! At a lecture some time ago regarding stress and its mechanism on PD symptoms , I deduced the following. Stress, worry, fright trigger the adrenal glands to act - "fight/flight reaction". The adrenals secrete excess acetylcholine - Actylcholine in excess disturbs the balance of dopamine secretion - Thus our carefully titrated Sinemet dosage is thrown out of whack. If a professional out there can correct or expand on this,I would appreciate it. [log in to unmask] (Mary Manfredi)