<fontfamily><param>Times New Roman</param><bigger>Debbie, The physiological changes in our brain and body, that go together with performing a "'mental" task are less evident than those which go together with emotions. Being afraid or angry, we feel our hart going faster and without knowing all details of what changes, we feel fear and anger as a reaction of our whole body: the fight or flight reaction. A heightened adrenaline level is a part of this reaction. This reaction or mental " state" is called "arousal". When we are performing a mental task like arithmetic or reading or trying to remember something, or all those activities that need concentation, physiological functions change in a different pattern that is called "activation". The neurotransmitter "acelylcholine" belongs to this "state". Acetylcholine is used in the parts of the brain that are involved in cognitive and memory functions. Changes that are caused by activation are, among others: a more efficient collaboration of different parts of the brain and a more regular hartbeat. We can not feel the changes that are taking place in our bodies being " activated" and that is why it is for many people natural to accept that fear and anger have physical consequences but not that performing mental tasks has physical consequences also. I hope I have answered your question. I don't know what exactly the consequences of "activation" are for the symptoms of PD. An influence might exist because acetylcholine is an antagonist of dopamine. They inhibit each other. When the brain uses more aceltylcholine it might be that dopamine is less inhibited and so the symptoms reduced. This is however only a guess. Maybe anyone else has some thoughts which have some firmer ground about this. Ida Kamphuis, Holland </bigger></fontfamily> Debbie wrote: >When talking to my father tonight (caregiver to my mother Joyce, 68/1 >year), he mentioned that he had heard that during sleep, sometimes PD >symptoms disappear. I recall reading this on the list.I also have read and >heard on this list that one can sometimes overcome PD symptoms (e.g., >freezing) by concentrating on them and working them out by going through >the motions step by step. What puzzles me is this: How is it that both >self-conscious activity and unconscious activity can alleviate some >symptoms? Any thoughts on this? Thanks > > > >Debbie White >[log in to unmask] > -------------------------------------------------------------- Vriendelijke Groeten / Kind regards, Ida Kamphuis mailto: [log in to unmask]