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Brian Collins wrote: [numerous posts containing very useful information, for which I am grateful.] I just found the paper on optimization of l-dopa dosage at http://new.parkinsons.org.uk/SCOS-3GMF2N.htm. Isn't that your work also? I seem to be approaching the intersection of the upward curve of dopamine requirement and the downward curve of tolerance. (What were the names of those two floating rocks in the Greek legend?) Other variables - when and what I eat, the amount of stress I experience, and who knows what else - seem to have become as important as size of dose. A while back you mentioned you were participating in a clinical trial of remacemide. How is that going? The idea of a pharmacological pallidotomy seems to me to be a very promising research direction. It would provide an opportunity for adjusting the effect by dosage variation, which you don't get with surgical pallidotomy. Phil Tompkins Hoboken NJ 60/9 Phil Tompkins