Dear Friends, I have written to Kathrynne for further details re: the liquid sinemet, as my mother does not seem to be responding to the sinemet as of two weeks... I've JUST passed along all of the comments regarding the timing of Sinemet (30-60 minutes prior to meals...) and am curious about the possibility that my mother may not even be absorbing the Sinemet at all due to poor peristalsis. Kathrynne suggested that I send a copy of my note to her for members of the caregivers/PWP groups to respond to. If you have had any experience/success (or otherwise) with liquid Sinemet, I would greatly appreciate that info., so that I can take it along to our next appointment with Mom's neurologist. THANK YOU in advance for any and all help/suggestions. Carole CG for Leah 75/3mo diagnosed Quoting from note to Kathrynne: THANK YOU for your counsel... your suggestions make so much sense, and I am convinced that we need to make some changes to at least give the Sinemet a chance... can you tell me any more about the Liquid Sinemet? (And WHY, oh why would a neuro. not have told us of the need to take Sinemet away from meals???) I can't help but feel that 2 weeks have been surrendered to The Disease, you know? Well... on with today and its hopes and changes. Kathrynne's response: (in part) << Sinemet 10'100 or 25/l00 l0 tablets << Ascorbic acid 1/2 level teaspoon << Water 1 liter << Shake until tablets disintegrate. This is a day's meds << They suggest a standard amount every hour. +++++++++++++++++++++++++++++++++++ "I would, however, query listmembers about their use of liquid Sinemet. The subject comes up regularly, and there's it with half Tang, half cranberry juice -- the vitamin C/ascorbic acid keeps the Sinemet stable throughout the day. Also, the amount of Sinemet is the amount the patient uses, not necessarily Sinemet 10/100, etc. The neurologist with whom I performed the nutrition research project likes liquid Sinemet for many of his patients, as it does provide relief for those with delayed stomach emptying." > (And WHY, oh why > would a neuro. not have told us of the need to take Sinemet away from > meals???) I can't help but feel that 2 weeks have been surrendered to The > Disease, you know? Carole, that's truly incredible!! The need to take Sinemet well before meals is very well understood, as is protein's interference with Sinemet absorption. Is this neuro a movement disorders specialist? (Carole: YES!!) If not, I would seek one who is -- your mother may not be getting optimal medication for her state. (Carole: Maybe the neuro was having a bad day??? Help!) At any rate, I would consider the Hearty Balance products. One problem I find with my PD clients is unplanned weight loss, which greatly enhances all aspects of the disease. If your mother has lost any weight, this should be stabilized. HB supplements can provide nourishment with less interference with levodopa. You can order via their website: http://www.balancenutrition.com/ or you can telephone: 1-800-473-3663.