Hi All, This is a message to introduce myself to the group. I have been a member of the Caregiver's list for about a month and have heard this is a great forum for information on PD. I am 31 years old, and am a CG for my mom who is 63 and was diagnosed almost 20 years ago with PD. She has been very independent for most of those years, but with increasing amounts of Sinemet. A few months ago she had a crisis with overmedication with Sinemet causing delusions. She was hospitalized for a few weeks and now she lives with me and my husband for the next few months until we get her stabilized with the introduction of Mirapex. For years she has had very bad end-of-dose problems (leg pain) on the Sinemet, which we are trying to fix. So far, we have not been able to reduce the Sinemet, and the leg pain continues. It breaks my heart to see her in so much pain; but I am terrified to just give her more Sinemet. I know it will make her feel better, but she will just need more and more to combat the pain as the days and weeks pass--as it has in the past. And now I know some of the awful side effects it can have on a person. I am glad to have her with me for the time being. I think she has been alone too long, and it calms her to be able to talk to me about her symptoms each day, etc. It also makes me feel more involved, and I enjoy being with her. In the past I had to stand back and let her fall apart every few months (terrible feeling); then step in to pick up the pieces (so to speak) and try to get her back to status quo. I am trying to take this opportunity to make life better for her--not just status quo again. Well, enough for now. If anyone has information on end-of-dose symptoms, I would love to hear from you. Thanks! Nicole