 |
 |
Hello Brian and Dennis, May I interrupt your discussion with a remark from my own observation? Thinking back I had no indication whatever that this was looming in my future. Absolutely no evidence. The happening that sent me to my GP, who sent me on immediately to a neurologist after eliminating alternate possibilities by having me take an MRA and other tests, was sudden and clear. I was operating a piece of garden machinery that presented a = weight load on my right hand and arm. the load tired out my arm and seemingly as a reaction the muscles in my right hand started to object a= nd vibrated. This was the tremor that was immediately recognized by my GP. It did not go away and did not get worse. I never had anything like that before. The only other problem I had before that was back trouble after lifting weights. This was clearly a muscle problem and may have been an earlier indication of PD. This problem did not precede diagnosis by more than two or three years. My theory in regards to your discussion is that I think that the healthy brain produces an over- abundance of dopamine which for the most part ( 80% ? ) goes wasted or ge= ts amortized by other substances, like MAO and others. We know there are plenty. Only when the death of cells causes an additional loss of dopamin= e, will a shortage become evident. = Does not this sound quite different than assuming that we can lose 80% of= producing cells = or 80% of dopamine production before we notice the effect? Just a thought. Will A. Kuipers 77 / 6 INTERNET:[log in to unmask]