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Kitty asked: "Is there anyone out there who has taken Eldepryl, and only Eldepryl, for two years, or three years, or even longer, without a substantial worsening of symptoms or the need to go on to Sinemet?" Kitty - I was on Eldepryl only for almost nine years (diagnosed in 89) and my only symptom has been a tremor on the left side (both arm and leg). The tremor has worsened over the years, and I quit Eldepryl about five or six months ago because I thought my body needed a break from it and I wanted to try some other medications and see what they would do on their own. I tried Amantadine for a few months--no effect. I tried Mirapex for a few months--no effect. I'm not sure what my next step will be. I have participated in a lot of Alternative ideas: removal of dental amalgams, chelation thereapy, and I take various antioxidants. I don't know if what I am doing is having any effect. Maybe the PD would have been slow progressing anyway, and maybe it isn't progressing slowly. Maybe I was diagnosed early. I've noticed that many on this list had PD for years before they were diagnosed, so there are many who went for years without Sinemet. I would like to believe (and actually, I do believe) that the Eldepryl and the Alternative treatments have made a difference. I wish you the best in all of your decisions. Sincerely, Joan