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Ivan, Interesting question about timing. I find that if I take my Sinemet CR 25/100 with something cold it take about 20 to 30 minutes to kick in. However, if I take it with something hot (tea, cocoa, etc.) it begins sooner (10 minutes or less). However, since I have been blessed to not suffer the nausea of others and I only take it in the afternoon to get through my worst time, I usually take it with cold liquid. don't forget how to laugh (and do it often) Marling McReynolds [log in to unmask]