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Hi Jeff.... Without knowing your wife's Parkinson's history/symptoms, that STILL sounds like a heckuva lot of Sinemet to take each day. The trouble with making a blanket statement such as mine is that this comment is based upon SOME PD-savvy and a strong gut-instinct (having lived with and battled this disease for 22 years myself). THAT'S not always the optimum way to get medical advice! <rueful smile> I'd suggest, if she hasn't yet seen a movement disorder specialist - a neurologist that SPECIALIZES in such diseases as Parkinson's, rather than a "mere" neurologist - that THAT should be something in your wife's immediate future! I know you're in a tough place watching your wife popping ever more pills without seeing any noticeable benefits. While people with PD often are encouraged by their respective neuros to do their own experimenting in settling on a daily med-dose, that is not ALWAYS the best way to deal with these drugs. All too often the individual with PD seemingly UNCONSCIOUSLY adds in one, two, three.. or even more pills over the period of a week or a month and as their symptoms increase FROM the additional drugs, they take even MORE drugs, hoping for symptomatic relief. I hope this isn't the case with your wife, but there's that gut-instinct telling me that it is. Barb Mallut [log in to unmask] ---------- From: Parkinson's Information Exchange on behalf of Jeff & Joan Heyser Sent: Saturday, February 21, 1998 10:50 AM To: Multiple recipients of list PARKINSN Subject: High medication dosage My wife (54/4) is taking a significant amount of medication an increasingly more frequent intervals. Every 1 3/4 hours (one and three quarters hours) she takes 1 Sinemet 25/100, 2 Sinemet CR 25/100 and 3/8 or 3/4 mg Mirapex. Somewhat less often when she is sleeping. Has anyone had experience with these levels of usage? Jeff Heyser ([log in to unmask])