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I realize that I seem to be posting the same questions over and over, but I'm exptremely frustrated, confused, and getting defeated by what's going on with my mother Joyce (68/1 year). She has been titrating up to Requip and using Sinemet and is just continuning to get worse in every way (that is, not one of her symptoms is better or even leveling out). She is now on 2.5 mg Requip 3x/day and 25/100 Sinemet in the morning and in the afternoon (that is 2x/day). I realize she is not on high doses, but shouldn't she feel SOME relief (she doesn't even feel any kick in with the Sinemet). Her worsening (and only) symptoms are rigidity in left hand (and arm a bit), bradykinesia, tightness in the chest, slurred speech, and an active tremor (not a resting one). Could it be that she has atypical PD and that these drugs will not help even one of her symptoms? Thanks Debbie White [log in to unmask]