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Dale, I have been experiencing the same thing. I don't know whether it is disease progression or accomodation and tolerance to the drug. I will see my MD in 2 weeks. I will let you know what he says at that point. Charlie Honie12440 wrote: > > Two or three weeks ago someone raised the question of requip wearing off. > > There is no question in my mind that the requip in by body is wearing off. > > I started Requip with very little difficultity about three months ago. In a > period of about 15 days I titrated up to 5mg. taken 3X a day for a total of > 15mg a day of requip. At the 15mg/day I was able to reduce my sinenet intake > to a 25/100 tablet to every four hours or more. That was an improvement from > the previous dossage of 25/100 tablet every 2 hours and 45 minutes. > > For the last 24 hours I have been off most of the time. Gradually the Requip > has been loosing its effectiveness. At 15mg per day I now require a sinemet > tablet every 3 hours or less. My doctor advised me to increase the Requip to > 20mg per day to see how that effects me and to try and take sinemet every 4 > hours again. > > I will keep the list advised of the outcome of this wearing off effect on me. > > Dale Severance > [log in to unmask] -- CHARLES T. MEYER, M.D. Middleton, WI [log in to unmask]