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Two different times within the past year I've been on two different antibiotics for non-Parkinson's related conditions. The first time I was on Flagyl and more recently I was on Bactrim. I was struck by the fact that for the duration of the time I was on each antibiotic.... one week apiece ... and for 3 or 4 days after I stopped taking each antibiotic I wasn't burdened by that AWFUL overwhelming daily fatigue and drowsiness that has been such a problem to me for the last several years. I'm curious. I know many of our List-family take or took Amantidine instead Sinemet and Amantidine IS an antibiotic as I understand it. Do those of ya who take Anantidine/Symmatril suffer on a near-daily basis from that "kick-ass Parkie fatigue," or not? I may be grasping at straws here, but I stopped taking Bactrim last Thursday, and the week I was on it, plus for five days after I stopped, I felt quite good. That's not to say I didn't have my usual PD symptoms, but there was NO fatigue or drowsiness during the time I took the antibiotic, and THAT felt simply WONDERFUL!! Thanks for your input.. <yawning> Barb Mallut [log in to unmask]