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Linda Carlton sent the following to the List, and I am not sure what it means in terms of PWP - or any of us for that matter. Can someone explain? Thanks Joy Graham >From: Linda Carlton <[log in to unmask]> >Subject: The interaction of melatonin and its precursors... >To: Multiple recipients of list PARKINSN <[log in to unmask]> > >J Pineal Res 1998 Jan;24(1):15-21 > >The interaction of melatonin and its precursors with aluminium, cadmium, >copper, iron, lead, and zinc: an adsorptive voltammetric study. > >Limson J, Nyokong T, Daya S > >Department of Chemistry, Rhodes University, Grahamstown, South Africa. > >[Medline record in process] > >Melatonin, a pineal secretory product, and its precursors, tryptophan >and serotonin, were examined for their metal binding >affinities for both essential and toxic metals: aluminium, cadmium, >copper, iron, lead, and zinc. An electrochemical technique, >adsorptive stripping voltammetry, showed the varying abilities of >melatonin and its precursors to bind the metals in situ. The >results show that the following metal complexes were formed: aluminium >with melatonin, tryptophan, and serotonin; cadmium >with melatonin and tryptophan; copper with melatonin and serotonin; >iron(III) with melatonin and serotonin; lead with >melatonin, tryptophan, and serotonin; and zinc with melatonin and >tryptophan. Iron(II) showed the formation of an in situ >complex with tryptophan only. These studies suggest a further role for >melatonin in the reduction of free radical generation and >metal detoxification, and they may explain the accumulation of aluminium >in Alzheimer's disease. > >PMID: 9468114, UI: 98127628