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Donna, I empathize with your dad. Since he's not feeling good and is depressed, he has little to lose by trying a different antidepressant. One that several members of this group have had success with would be a reasonable candidate. I know med changes can be a hard sell to a parent who's feeling bad and is depressed, but the only alternative is to stick with his current meds and he knows they aren't working. (Pretty complex logic, huh?) I notice he's taking Serzone. Does he tolerate it well? Has he tried other antidepressants? I tolerate PD meds well (Sinemet, Eldepryl, Mirapex) but find big differences in my reaction to various antidepressants. Some enhance Sinemet's effectiveness; some interfere with it (for me anyway). I've had the best luck with Zoloft and Wellbutrin; the worst with Serzone (a very uncomfortable experience). Zoloft seems to be generally well tolerated by many PWP's. Even if he's tried several with no positive results, as important as antidepressants can be to his general well-being, I think he should keep trying (and you should keep pressing him) to find the right one. You'll know it when he does. I suggest you consider consulting a psychiatrist in your dad's search for the right antidepressant. I've found them to be much more knowledgeable about antidepressants than neurologists. After all, it's their specialty. You'll notice that almost all docs will prescribe antidepressants--I've known ob/gyn's, internists, geriatricians and primary care physicians (and, I suspect, others whom I've forgotten) who regularly prescribe them. I believe there are a number of reasons for that, not the least of which is that the newer psychotropics are effective and relatively free of major side effects. That makes them easy to prescribe but it doesn't mean the prescribing physician is expert in their use. I've read our List members insist many times that movement disorder specialists are the right choice for PWP's. I feel the same way about psychiatrists for those of us who need help with depression. For my money, I'll stick with the specialist. Bob Bowling 51/9 Overland Park, KS ~~~~~~~~~~~~~~~~~~~~~~~~~ <[log in to unmask]> -----Portions of Original Message----- Date: Fri, 6 Mar 1998 From: "Donna A. Bassolino" <[log in to unmask]> Subject: Requip ? Anyway - anyone on Requip ? What dose ? My dad recently switched from Mirapex to ReQuip. This is his third week @ 3 25mg pills 3x a day......But he still isn't feeling well - nausea depression/confusion - leg pain......But its been a year now since his DG - and I hate to say it but he's had maybe one good day ! He can't keep exisiting at this level (or lack of) quality of life. ANybody have good experiences - advice ? We'll try anything. ~~~~~~~~~~~~~~~~~~~~~~~~~