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Hi Ron, Re: chewing 1/2 a Sinemet CR to get a quick response...... > > This is OK. It is not the least expensive choice. Regular Sinemet or generic > carbidopa/levodopa is less expensive medicine that provides more efficient usage. > > It may be that using regular carbidopa/levodopa with a COMT-inhibitor would > allow smaller dosage at 6-hour intervals for most efficiency in the > pharmaceutical sense. > I've been on Tasmar(R) / tolcapone 200mg. @ 6 hour intervals for 1 year and find it (combined with 50/200 Sinemet CR) gives me a very smooth ride. (Incidentally, breaking the 50/200 tablets in 1/2 and then taking a 1/2 tablet every 3 hours makes it even smoother, as long as you can remember to take your meds on time) > >(The price of tolcapone or entacapone is not known to > me. It may be more expensive.) > > best wishes > -- > Ron Vetter 1936, '84 PD dz paradise is feeling good, not a place to go > [log in to unmask] > http://www.ridgecrest.ca.us/~rfvetter > I hadn't considered the economics of this since I haven't had to pay for this. Tolcapone is available here in Canada at the local pharmacy. The price for the 200mg. tablet is 100 for 350.00 or $3.50 a pop and you take 3 a day for $10.50 a day. This is in Canadian depressed dollars but translates to $2.45 a tablet in US dollars or roughly $7.35 / day. It ain't cheap that's fer sure!!!!!!!!!! But then as long as companies like Roche pick up the tab for research I guess we can expect that sooner or later they will have to extract their "pound of flesh". The "Glory" doesn't appear on the quarterly report bottom line. It has been my good fortune to receive this medication at no cost as part of a clinical study and even when study meds are no longer available I expect I will be reimbursed by my benefits program. Thanks and all the best............Murray . [log in to unmask]