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I found this article: Why is smoking so hard to give up? Researchers have found that smoking blocks an enzyme in the brain which = breaks down a chemical called dopamine. So the dopamine levels get high and smokers feel more alert . When they = stop smoking dopamine levels fall and they feel unwell. Drugs like = moclobemide which keep the dopamine high could help people to stop = smoking. The low dopamine levels when smokers are not smoking also causes them to = be vulnerable to the actions of alcohol , cocaine , amphetamines and = heroin and that is why scientists speculate they may experiment and = become addicted to them as well..