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David Langridge wrote:> > I have seen many postings such as this; > " Note It is particularly important that the potentially fatal interaction > between Selegiline [DEPRENYL/ELDEPRYL] and Pethidine is noted." > but cannot find any actual medical authority. I might be having a back > operation shortly which could involve me being given Pethidine ( Demerol) > for pain relief. My nuerologist said there,s no interaction problem to > worry about. If there is some interaction I would like to give him some > factual evidence from pubished research etc and not just hearsay. Any info > would be most welcome. > David Langridge As a non-professional, I'm hesitant to say this, but if your neuro really doesn't know about the dangerous Demerol-Deprenyl interaction, maybe you should find another neurologist. The Physician's Desk Reference is the *official* compendium of all the approved prescription drugs in the U.S., because it contains virtually complete the "package insert" information that is required by the FDA. I can't imagine an MD who is not familiar with the PDR, in fact practically all own the latest annual edition. The article on Demerol (U.S. brand name) says in part: "Meperidine is contraindicated in patients who are receiving monoamine oxidase inhibitors [e.g., selegiline or Deprenyl] ... Therapeutic doses of meperidine have occasionally precipitated unpredictable, severe, and occasionally fatal reactions [in such patients]..." OK? Cheers, Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013