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Hello Fellow Tasmar takers, Yesterday I visited my neuro doc and we decided that I would try taking this drug. He immediately wrote an Rx for a full liver function test. He wants to review the results PRIOR to my taking the drug.=A0 The test is to be continued on a=A0 monthly schedule for 6 months. Since, tolcapone is absorbed by the= small intestine and metabolized by the liver, there seems to be relevance for= taking this precaution. I reviewed the many posts relating to this drug, and did not see anyone mentioning this 'inconvenience'. I checked some of the literature and found that=A0 a small number of patients may develop raised levels of alanine aminotransferase (ALT) and aspartane aminotransferase (AST) between 6-12= weeks after the start of treatment. In those cases where the subjects stopped their treatment, the levels= returned to normal within 2-4 weeks of discontinuing treatment without any other hepatic adverse effects being observed.=A0 In patients who continued tocapone= treatment, liver enzyme abnormalities resolved spontaneously without sequelae (morbid condition following as a consequence).=A0 More patients developed elevated= ALT levels than AST levels. The reason for this phenomenon is not known, and no obvious differences were seen between patients with or without elevated transaminases in terms of previous or concomitant medical conditions or medications.=A0=20 The preceeding is paraphrasing sections of an article in Neurology 49, September 1997, p. 665-670, written by C.H. Waters, MD: M. Kurth, MD; et al Does anyone have the insert that comes with the medication? Can you please check it?=A0 I do not mean to alarm anyone, but this may be important info. Thanks, Margaret [log in to unmask] DOB: 1941/Dx: 1980/Cured:ASAP Slogans wont do it/Hard work will