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This is one of the posts re" Lewy body-- the other follows. >Date: Wed, 25 Feb 1998 09:20:29 -0800 >From: "J. R. Bruman" <[log in to unmask]> >Subject: Re: Lewy Body disease >Sender: Parkinson's Information Exchange <[log in to unmask]> >To: Multiple recipients of list PARKINSN <[log in to unmask]> >Reply-to: [log in to unmask] >MIME-version: 1.0 >X-Orcpt: rfc822;[log in to unmask] > >Camilla H.Flintermann wrote: >> Carole wrote: >> SNIPPED >> >The neurologist recommended stopping the PD medication attempts-- >>saying that >> >it appears that Mom's symptoms stem from some other disease with the PD >> >"look". And so.... here we are. Three days off of Sinemet in the >>midst of a >> >cloud of mystery. Months ago, my sister, Ann, and her husband had >>researched >> >via internet and come up with their "guess" that Mom might have "Lewy >>Bodies >> >Dementia"... has anyone had experience/acquaintance with this disease? It >> >seems that it mirrors some of the symptoms of both PD and Altzheimers... no >> >treatment, though, alas (at least, as far as we have been able to research >> >thus far). > >The news about Lewy Body disease is not so good, but here are a few >minor tips that may help in your internet research: The most common >term is Diffuse Lewy Body Disease (DLBD), but that is only a vague >description of something which combines the motor deficits of >Parkinson's with the dementia of Alzheimer's. Lewy (pronounced >"leh-vee") bodies are distinctive microscopic spheres found at autopsy >in the brains of Parkinson's victims. It once was thought that Lewy >bodies were the unique hallmark of PD, but since then they are >associated with several other neurodegenerative diseases. Their >distribution in the brain seems to be distinctive for each one. >The most recent research suggests that Lewy bodies are clumps of a >common protein called alpha-synuclein, and workers are looking for >what causes the clumping, in hopes that may lead to a pathologic >key. >Joe > >J. R. Bruman (818) 789-3694 >3527 Cody Road >Sherman Oaks, CA 91403-5013 >