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it seems to me (non medical professional) that Sinemet or generic is the best choice in the smallest dose that works. for this to be accomplished, it is necessary to take enough carbidopa to have the carbidopa slow the rate of enzyme metabolism of levodopa to dopamine in the blood. this is necessary to get best effect and to MINIMIZE the nausea - which is the brain stem area detecting "poisonous" level of dopamine and making one feel ready to vomit. suggest using Lodosyn (carbidopa only tablet or portion) along with half a 25/100 carbidopa/levodopa tablet four times a day and take on arelatively empty stomach with some orange juice. follow with a plain cracker or pretzel or half a cup of dry multigrain cheerios. then do not eat a lot of protein - but do eat some fruits, vegetables, bread with whole grains about 30 to 45 minutes after each dosage. Taking him to a support group does little or nothing. He must be supported - (take charge of his-self to try to live a little at least; id est, 'break' the depression - his not caring to try to do his best) by deciding to join to support himself and others - for it to be a positive exerience. This lack of actually pitching-in by most of the persons who we have on our small support group list is the most lacking aspect of my goals as primary leader of the group. As many have come and gone from the parkinsn listserv cyber-family, so it happens with the face-to-face groups. just an hour a month will do little or nothing. if you care enough to become involved to inspire him to give living lnger a real effort, he will do that. If no one convinces him to be spunky, he will soon cease to be is the frank probability. Our need to live is small if our will to live is drowned by lackof feeling good. feeling good is the result of loving a minimum of one person - not that I recommend being a hermit - it is better to love (care about) self and others - the more the merrier. it works although most doubt it. love, ron Ronald Vetter 1936, dz PD 1984, carbidopa/levodopa, Mirapex, selegiline [log in to unmask] Ridgecrest, California http://www.ridgecrest.ca.us/~rfvetter