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Those List members advocating the registering of PWP might be interested in noting that the Cleveland Clinic Center for Colon Polyps and Colon Cancer has such a list of colon patients whose relatives, because of inherited gene mutation, are at risk of getting colorectal cancer. In the Spring issue of the Cleveland Clinic _Vistas_ (vol 6 #1 pp 14-15) it says "Because their risk is so high, these patients should be in a registry that provides scheduled screening examinations for early detection of precancerous polyps and cancer." Quoting from the article, "The Cleveland Clinic Jagelman Registries ... contain information on more than 700 families and 5,000 individuals who are at high risk for one of the five forms of inherited colorectal cancer due to their family and personal history. Some patients in the registry have undergone genetic testing to determine what specific mutations are present in the DNA." In its 20-year history, the Jagelman Registries have played an important role in advancing the understanding of inherited colon cancer by providing a wealth of information on high-risk individuals and families. Cleveland Clinic colorectal cancer specialists recently have begun work on a National Cancer Institute project to develop a larger, population-based colon cancer registry. The Clinic participates in a research consortium that is one of six cancer study groups selected for the project. "By comparing data from the known high-risk population in the Jagelman Registries with that from other centers, we hope to better understand the interaction between environmental effects and inherited colon cancer risk." -------------------- Sid Roberts 68/dx3 [log in to unmask] Youngstown, Ohio