Dear listfriends, At wednesday March 18, I went for the first time to my new neurologist, Dr. Joel Freitag here in Waco, Texas. The weeks before it I had bad "off" periods and increased the doses of Sinemet and Permax. My schedule was as follows: 7.30 9.30 12.30 15.30 19.00 22.00 Sinemet 62.5 1 Sinemet 125CR 1 1 1 1 1 1 Permax 1.0 1 1 1 1 1/2 1/2 The Sinemet 62.5 in the morning is used as a "kick in". If I don't do so, I'll stay "off" till my second take of the day. Somewhere on the day I had to take a Sinemet 62.5 to kick in again We agreed in start taking Tasmar. The results are very promising. I have never had problems with taking any medication, no nausea, no headache, nothing. I started with 2x a day 100 mg Tasmar. The first day was remarkable : no "off" period. The second and the third day were horrible, but I had forgotten to get Permax from the Pharmacist so I spread out what I had. After a week I felt better again and started increasing the time between two moments of eating my "candy". After two weeks my schedule was as follows : 7.30 10.30 14.30 18.30 22.00 Sinemet 62.5 1 Sinemet 125CR 1 1 1 1 1 Permax 1.0 1 1 1 1/2 1/2 Tasmar 100 1 1 This was still too much, because I had long periods of dyskenesia. Thursday April 2 I went for my second consult. We agreed to decrease the doses of Sinemet and to increase the doses of Tasmar. Today I used too little Sinemet and Permax, but I hadn't too long "off" periods. I used today 3 Sinemet 125 CR, 1 Sinemet 62.5, 3 Tasmar 100, and 3 Permax 1.0. I think I need 1 more Sinemet, but maybe the Tasmar will do its work and can I stay on 3 Sinemet and 3 Permax. That means I use 50 % less Sinemet and 40 % less Permax and that while I'm only using half of the advised (3x200mg) doses. I am very satisfied and am curious to know how long I will benefit this COMT-inhibitor and how low I can go in my Sinemet and Permax. Warm greetings from a happy Dutchman in Texas, 48/9, Sinemet 1x 62.5, Sinemet 3x 125CR, Permax 3x 1.0, Tasmar 3x 100 **** Life is a loan, to live is an art, to live happily is a gift, to give is to live, to love is to give and to live, to cope with PD is all, I thank God daily that He gives me this loan and I will pay him back***