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>From: Alastair Wyse <[log in to unmask]> snip > The first thing I read on PD after I was diagnosed was Dr.Harvey >Sagar's book " Parkinson's Disease " in which he explains dyskinesia >as occuring at max dopamine or peak dose ie too much dopamine . but >very interestingly he says this occurs 1/2 hour after taking L-dopa . the time will vary with dose amount and threshold effective level. >He also says that there is an end of dose dyskinesia for which he has >no explanation . > What he is describing in his peak dose dyskinesia is the first phase >of biphasic dyskinesia because the maximum concentration of dopamine >in the brain occurs 1 to 1 1/2 hours after taking the L-dopa . the threshold where dyskinesia initiates is a variable with each person and changes from "it never occurs" with some newly-diagnosed to a level near (or even below) the effective medicaton level. I >dont believe in peak dose dyskinesia except where the first and >second phase have run together . I sometimes get this effect when I >do not tke enough L-dopa . Too much L-dopa does not produce >dyskinesia but slight dizzyness . see above > Dr . Sagar along with much of the medical profession are twisting >the data to fit their theories . I believe that concentrating too >much on the different receptors etc. is not seeing the wood for the >trees . perhaps the global data set is not available. there is a vast difference in my response today compared to my response in 1984 or 5 years ago. > peace > Alastair ( [log in to unmask] ) my best to all. love, ron