As a supplement to the journal _Neurology_ 1998;50(Suppl 3):Sl, C. Warren Olanow, MD, FRCPC, and William C. Koller, MD, PhD wrote "An algorithm (decision tree) for the management of Parkinson's disease: Treatment guidelines." It is one of the best and up to the minute accounts of what is happening in PD. I wish I could reproduce the entire 50 some odd pages here for everyone to read but the copyright laws would prohibit that. Here, below, is a short exerpt dealing with exercise and diet under the supplement's heading, NONPHARMACOLOGIC TREATMENTS Exercise. Exercise is an important adjunctive therapy for PD and can be one of the most beneficial activities in which the patient is involved (breakout 2).10 Although exercise has not been shown to have direct effects on the cardinal symptoms of bradykinesia, tremor, postural instability, or rigidity, it can slow the secondary effects of these problems that further limit mobility and functional activity. 11,12 *** *** [The chart Breakout 2 should go here with the following caption:] Breakout 2. Although exercise has not been shown to directly change the cardinal symptoms of PD, a regular, focused exercise program that includes aerobics, stretching, and strengthening activities can have positive effects on mobility and mood. Patients should be educated about the positive effects of exercise on mobility and mood. An exercise program should include aerobic, strengthening, and stretching activities. One does not replace the other. Aerobic exercise should be done at a training heart rate of 60 to 70% maximal heart rate. Stretching should be done when muscles are warm, and strengthening should be done with light weights. The goal should be to improve flexibility and strength but not bulk. The emphasis should be placed on the extensor muscles to counteract the flexor postures that tend to develop in PD. A reasonable goal is to work up to 20-minute exercise sessions three times a week. Patients who are interested in an exercise program but are not sure how to get started should be referred to a physical therapist or a PD exercise group. Before an exercise program is started, other potentially complicating medical problems, such as heart disease, should be ruled out. The baseline level of fitness can be determined by measuring maximal heart rate. Other limitations of mobility, such as decreased range of motion, should be identified to minimize the risk of injury. Non-weight-bearing exercise (e.g., water aerobics) may be particularly beneficial for a PD patient. *** *** [The chart Breakout 3 goes here and has the following caption:] Breakout 3. Establishment and maintenance of good nutritional habits are integral components of the manage ment of PD. Clinicians should obtain a thorough dietary history and identify current eating habits. It is essential to help patients become aware of their dietary habits and to educate them about the elements of a balanced diet and about techniques for successfully altering poor eating habits. Nutritional counseling may be beneficial in some patients. Nutrition. Patients with PD are at increased risk for poor nutrition, weight loss, and reduced muscle mass in comparison to healthy controls.13,14 Good nutrition is essential to the overall well-being of patients with both early- and late-stage disease. Although no specific diet is required, patients should eat a balanced diet that contains sufficient fiber and fluid to prevent constipation and enough calcium to maintain existing bone structure. Although patients often ask about dietary protein restriction, this is usually a concern only for patients with late-stage disease, in which amino-acid competition for levodopa absorption causes erratic responses to levodopa therapy.15 It is important to establish and maintain good eating habits in patients with early PD (breakout 3). Clinicians should obtain a thorough dietary history and identify current eating habits. This is an opportunity to identify those patients who are following nontraditional diets that may be harmful. Helping patients become aware of their dietary habits and educating them about the elements of a balanced diet and the techniques to successfully alter poor eating habits is essential. Increasing the quantity of fiber and fluids in the newly diagnosed patient is useful and may prevent or minimize constipation later in the course of the disease. 16 In some instances, nutritional counseling with a clinical dietitian may be of value. Patients who have difficulty maintaining a balanced diet may be candidates for a supplemental multiple vitamin, with or without calcium supplementation. A large body of literature supports a role of oxidative stress in the pathophysiology of PD .17-21 However, at present there is no evidence that supraphysiologic or megadoses of antioxidants (e.g., a-tocopherol or vitamin E) alter the course of the disease '22-24 and such treatments may be very costly. On the other hand, there is no current information suggesting that these agents are harmful. [The numbers within the above text from 1 thru 24 represent footnotes which I have not reproduced here.] -------------------- Sid Roberts 68/dx3 [log in to unmask] Youngstown, Ohio