In a message dated 98-04-08 21:06:29 EDT, you write: << Meanwhile, Re: your query on increasing Carbidopa, I would say that the only circumstance where it might be worth trying is if your current intake is less than 100 mg per day of Carbidopa. The accepted figure is 70 mg/day;- more than that would not be effective in saving levadopa, because there is no more to be saved. On the other hand, the upper level of Carbidopa is not critical : I would expect that most of you folk are currently taking nearer to 200 mg than 100 mg of Carbidopa, and it isn't doing you any harm, so if you want to experiment there is minimal risk. The first symptoms of too much should be a noticeable lack of 'Get-Up-and-Go !,and a general malaise. Good luck. >> i may be wrong but I have believed for years-- I think I got it from Dr Delong ( the palli expert from Emory) that one can benefoirt from 150 mg a day and that anything over 300 mg a day is toxic. At any rate, corbidopa is not a totally benign drug. Regards, WHH