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Hi Barbara, The only problem I'm aware of with ginger ale is if the person has heartburn -- carbonated drinks can make this worse. I have not heard that carbonation will make Sinemet work faster or eliminate the controlled-release function of Sinemet CR. However, if anyone has references to the contrary, I would be very happy to get those, I will immediately update my information! Best regards, Kathrynne -- Kathrynne Holden, MS, RD "Nutrition you can live with!" Medical nutrition therapy http://www.nutritionucanlivewith.com/ Tel: 970-493-6532 // Fax: 970-493-6538