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I started Tasmar at 100mg three times a day about three weeks ago. I was taking 7 mg Requip (reduced to 5), and 50/200 Sinemet CR - both also three times a day. Also Eldepryl morning and noon. Effect on motor symptoms was immediate and fantastic. Extended on time from 5 to 7 hours plus. BUT, after about a week I noticed I couldn't make decisions, had sleepless nights with high anxiety (both extremely unusual for me) , nightmares when I did sleep and my wife described me as frantic. Cut back on Eldrepryl to one in AM and Tasmar to 50 mg (I cut tabs in half) and I am doing much better -----Original Message----- From: Phil Tompkins <[log in to unmask]> To: Multiple recipients of list PARKINSN <[log in to unmask]> Date: Friday, April 10, 1998 4:09 AM Subject: Re: Tasmar - starting gradually A week ago my neuro started me with 100 mg one time a day, to be increased each week by another 100 until I reach 600 mg per day. I'm to decrease my Sinemet according to my experience of how much less I need - right now that's about 25/100 four times a day. We don't know right now how much of that I'll need later. I'm to continue my regular doses of Permax and Eldepryl. Phil Tompkins Hoboken NJ 60/9