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In a message dated 98-04-08 11:00:44 EDT, you write: << Also what are your thoughts (everyone on the PD network, not just Brian) on attempting to increase "on" time by increasing the amout of carbidopa taken with the levadopa? I thought about this approach before trying the Permax; Mirapex; Requip; or Tasmar methods. Thank you Margaret Mates Margaret, Be careful with carbidopa . It can be a bad actor (peripheral nerve damage if I remeember correctly). If my memory serves me correctly: After the first 150 mg in a day, the sites are saturated and more than 300 mg a day becomes toxic. Therefore, unless you are getting less than 150 mg from your Sinemet, your body can't use extrea Lodosyn (speklling?) Regards, WHH