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Thank you for your very enlightening response to my question. You are generally right about Shy-drager syndrome and PD except that in his case, he had PD for ten years before SDS reared its ugly head. His PD symptoms have always and still do respond very well to sinemet. He takes 500mg of sinemetCR daily and needs more except that it makes his dementia worse and his SDS. With the sinemet he takes NADH. He used to take Eldepryl with very good results until the blood pressure became an issue, so he doesn't take that any more. It really is a big balancing act with him, trying to get the right balance of neurotransmitters working without lowering his BP so much that he can't stand. You are right about the reconnections making the brain continue to improve. Last night we were watching TV Bloopers and he was laughing out loud and making comments about each part. He also informed us that he intended to stay up until this show was over. His helper commented to me that he had never seen Ken laugh like that. Usually a small smile is all we get and a year ago this show would not have made sense to him. He used to have a wonderful sense of humor, but it had been absent for several years. It seems that Aricept is bringing it back--- what a miracle! Barbara Smith,CG/Ken/70/17