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When I went on Permax (in addition to Sinemet 25/100 and Eldypril) my muscle tightening disappeared almost immediately--when I was still at a very low dosage. I hope that helps. Nancy Shlaes Leanne and Michael McGillivray-Lott wrote: > Hi, > > I am writing on behalf of my dad Don (62/20) who is wondering if anyone has > any tips/suggestions that might help him. During his off time his muscles > tighten and cause him great discomfort. He gets a small amount of relief > lying down and trying to stretch them but not much. He would appreciate any > advice. > > Thanks > Leanne > [log in to unmask] > Point Clare, NSW, Australia