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Hello, mirapex has taken the place of Permax for me.Following neurologists directions I was taken down to bare bones as the saying goes by graduating off Permax (3 perday) and gaduated to Mirapex(4 1/2 )This was over a period of 3 months and hasnow only adjusted to my needs I still am taking 4 sinemet cr and 1 regular sinemet and 2 eldapryl . The elderpryl to be replaced at the end of this month with requ.? I was told that Mirapex takes the minimum of two weeks before one feels the benfit one way or the other. The balancing act seems to get more complicated as time passes.initial side effect rip van winkle all over again but got over that after a couple of weeks. lets all hold in there a cure will come !!!!!! Have a good day Margaret Clark59/8