hi all i have been astonished at the response from my cyber family to my plea for help/advice in re the apo generic levodopa/carbidopa that i have been taking for the past three months instead of sinemet but i guess i shouldn't be astonished this is just more proof of when we need us we are here it's been interesting, to say the least i have gone through some major life changes during [roughly] the same time frame so it may have been tempting to just 'blame all the stress" [echoes of "it's all in your head" assumptions??] however, based on responses from 17 of you, [summarized at the end of this message] i think it's quite possible that i've been having a negative reaction to the apo generic i can prove/disprove this idea very simply: i will switch back to the brand name sinemet tomorrow re the tolcapone prescribed for me i think i will wait a couple of weeks for my brain to adjust to this latest change in the chemical soup recipe [both of the above after consultation with my neuro, of course] **********summary of 17 responses ******** note 1: all responses are from parkies or their caregivers note 2: description of medications mentioned: brand name = sinemet made by dupont-merck generic apo = made by apotex in canada generic endo = made by dupont in canada generic teva = made by merck in israel 2 better response to generic than brand name 8 no difference in response to generic or brand name of these 2 mentioned a generic made by merck 3 mentioned a negative reaction to brand name cr 5 negative reaction to generic required change back to brand name 2 response to apo generic worse than to brand name response to endo generic better than to apo generic i.e. response to endo was equivalent to brand name 17 total responses thanks gang! your cyb-syb janet janet paterson 51/10 - sinemet/selegiline/prozac almonte/ontario/canada - [log in to unmask]