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I read Brian Collins' post on the subject hastily- my only comment is about the Controlled Release levodopa mechanism. As I understand it, the only difference between Sinemet CR and standard Sinemet is that the former is made with an inert binder that makes it slower to dissolve. That's why the CR tablets can be bigger without risk of overdose, and why they tell you not to chew or break them. Cheers, Joe J. R. Bruman (818) 789-3694 3527 Cody Road Sherman Oaks, CA 91403-5013